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    Gadobutrol (API) – Pharmaceutical intermediates product from Bio Green Chem

    Gadobutrol (API)

    Gadobutrol (CAS 770691-21-9), the macrocyclic, non-ionic gadolinium contrast agent API, at an assay of 98.0-102.0% on the anhydrous basis, with free gadolinium held to 0.0003%. For MRI contrast-agent formulation.

    MRI contrast-agent formulationCentral nervous system, body and vascular imaging mediaPharmaceutical development
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    Cyclen (1,4,7,10-Tetraazacyclododecane) – Pharmaceutical intermediates product from Bio Green Chem

    Cyclen (1,4,7,10-Tetraazacyclododecane)

    Cyclen (1,4,7,10-tetraazacyclododecane, CAS 294-90-6) at 98% minimum, the twelve-membered macrocycle from which DOTA, DO3A and the macrocyclic gadolinium contrast agents are built. Supplied as a white to off-white powder.

    DOTA and DO3A synthesisGadolinium contrast-agent manufactureRadiopharmaceutical chelator development+1 more
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    Cyclen Tetrahydrochloride – Pharmaceutical intermediates product from Bio Green Chem

    Cyclen Tetrahydrochloride

    Cyclen tetrahydrochloride (CAS 10045-25-7), the stable salt form of the cyclen macrocycle, at an assay of 98.0-102.0% with chloride at 40-45%. The easier-to-store route into DOTA, DO3A and macrocyclic chelator synthesis.

    Stable cyclen source for DOTA and DO3AGadolinium contrast-agent synthesisMacrocyclic chelator preparation+1 more
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    DOTA (Tetraxetan) – Pharmaceutical intermediates product from Bio Green Chem

    DOTA (Tetraxetan)

    DOTA (tetraxetan, CAS 60239-18-1) at 98% minimum purity, the octadentate macrocyclic chelator that forms the gadolinium complex of gadoterate and anchors radiometals in DOTA-based radiopharmaceuticals.

    Gadoteric acid and gadoterate meglumine manufactureDOTA-based bifunctional chelatorsRadiopharmaceutical precursors+1 more
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    DO3A Trisodium Salt – Pharmaceutical intermediates product from Bio Green Chem

    DO3A Trisodium Salt

    DO3A trisodium salt (CAS 217973-03-0), the cyclen triacetate with one ring nitrogen left free: the branch point for the macrocyclic contrast agents gadoteridol and gadobutrol. Specification agreed with the quotation.

    Gadobutrol manufactureGadoteridol manufactureMono-functionalised macrocyclic chelators+1 more
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    Cyclen Butanetriol Tetrahydrochloride (Gadobutrol Intermediate) – Pharmaceutical intermediates product from Bio Green Chem

    Cyclen Butanetriol Tetrahydrochloride (Gadobutrol Intermediate)

    Cyclen butanetriol tetrahydrochloride (CAS 156077-56-4), the late-stage gadobutrol intermediate carrying the finished trihydroxy side chain, at 98% minimum with residual methanol and toluene held to ICH Q3C limits.

    Gadobutrol manufactureNeutral macrocyclic gadolinium complexesMRI contrast-agent development
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    Gadoteric Acid (Gd-DOTA) – Pharmaceutical intermediates product from Bio Green Chem

    Gadoteric Acid (Gd-DOTA)

    Gadoteric acid (Gd-DOTA, CAS 72573-82-1), the gadolinium complex of DOTA and the active moiety of gadoterate meglumine, the ionic macrocyclic MRI contrast agent. Specification agreed with the quotation.

    Gadoterate meglumine manufactureContrast-agent formulation developmentAnalytical reference material
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    4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane – Pharmaceutical intermediates product from Bio Green Chem

    4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane

    4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane (CAS 57280-22-5), the acetonide-protected meso epoxide that supplies gadobutrol's side chain. Offered in 98%, 99% and 99.9% grades as a colourless to pale yellow liquid.

    Gadobutrol side-chain building blockProtected triol and aminodiol intermediatesAsymmetric catalysis research
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    2-Fluoro-N-methyl-4-nitrobenzamide – Pharmaceutical intermediates product from Bio Green Chem

    2-Fluoro-N-methyl-4-nitrobenzamide

    2-Fluoro-N-methyl-4-nitrobenzamide (CAS 915087-24-0), the nitro precursor of 4-amino-2-fluoro-N-methylbenzamide, which forms the benzamide half of the prostate cancer drugs enzalutamide and apalutamide. Specification agreed with the quotation.

    Enzalutamide manufactureApalutamide manufactureMedicinal chemistry building block
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    Peramivir Isoxazoline Intermediate – Pharmaceutical intermediates product from Bio Green Chem

    Peramivir Isoxazoline Intermediate

    The isoxazoline peramivir intermediate (CAS 229613-93-8, C18H30N2O5), formed by nitrile oxide cycloaddition and carrying the stereochemistry of the drug's ring. Supplied at 98% minimum with the diastereoisomer held to 0.1%.

    Peramivir manufactureCyclopentane neuraminidase inhibitor synthesisAntiviral research
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    Triphenylacetic Acid – Pharmaceutical intermediates product from Bio Green Chem

    Triphenylacetic Acid

    Triphenylacetic acid (CAS 595-91-5) at an assay of 98.0-102.0%, the bulky carboxylic acid behind dirhodium triphenylacetate catalysts, with its decarboxylation product triphenylmethane held to 0.30%.

    Dirhodium carboxylate catalystsMetal carboxylate complexesOrganic and pharmaceutical synthesis+1 more
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    Bromocyclopropane – Pharmaceutical intermediates product from Bio Green Chem

    Bromocyclopropane

    Bromocyclopropane (cyclopropyl bromide, CAS 4333-56-6) at 98% minimum with water held to 0.5%. The standard entry point to cyclopropyl Grignard reagents and cyclopropylboronic acid for installing cyclopropyl groups in drug and crop-protection molecules.

    Pharmaceutical and agrochemical intermediateCyclopropylboronic acid preparationCyclopropyl Grignard and lithium reagents+1 more
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    3-Iodooxetane – Pharmaceutical intermediates product from Bio Green Chem

    3-Iodooxetane

    3-Iodooxetane (CAS 26272-85-5) at 98% minimum, identity confirmed by proton NMR. A reactive building block for attaching the oxetan-3-yl ring, the compact polar replacement for gem-dimethyl and carbonyl groups in drug design.

    Pharmaceutical discovery and developmentOxetane building blockCross-coupling and alkylation chemistry
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    2-Methyl-3-(trifluoromethyl)aniline – Pharmaceutical intermediates product from Bio Green Chem

    2-Methyl-3-(trifluoromethyl)aniline

    2-Methyl-3-(trifluoromethyl)aniline (CAS 54396-44-0), the substituted aniline that forms the aryl half of the veterinary anti-inflammatory flunixin. A fluorinated building block for pharmaceutical and agrochemical synthesis; specification agreed with the quotation.

    Flunixin and flunixin meglumine manufactureVeterinary pharmaceutical synthesisFluorinated aniline building block+1 more
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