Gadoteric Acid (Gd-DOTA)

About This Product

Gadoteric acid is the gadolinium(III) complex of DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, with the formula C16H25GdN4O8, molecular weight 558.6 and CAS number 72573-82-1. In the complex, gadolinium is held by the four ring nitrogens and four carboxylate groups of the macrocycle. Of the four carboxylates, three balance the charge of the gadolinium ion and the fourth leaves the complex with a single negative charge, which is why gadoteric acid is formulated as a salt with the amino sugar meglumine. The resulting gadoterate meglumine is an ionic macrocyclic contrast agent, and its DOTA cage gives it among the highest kinetic stability of the gadolinium agents in clinical use, the property that matters most since regulators restricted the less stable linear agents. In manufacture the critical quality points are complete complexation, with free gadolinium and free ligand both controlled, together with related substances and residual metals, and they are agreed against the formulator's specification. It is used in the manufacture of gadoterate meglumine injections for MRI, in contrast-agent formulation development and as a reference material in analytical work. Bio Green Chem supplies gadoteric acid with the assay, free gadolinium, free DOTA, related substances and water specification agreed with the quotation. Regulatory documentation for pharmaceutical use is confirmed at enquiry.