2-Fluoro-N-methyl-4-nitrobenzamide

About This Product

2-Fluoro-N-methyl-4-nitrobenzamide has the formula C8H7FN2O3, molecular weight 198.2 and CAS number 915087-24-0. It is the N-methyl amide of 2-fluoro-4-nitrobenzoic acid. Its importance comes from what it becomes. Reduction of the nitro group gives 4-amino-2-fluoro-N-methylbenzamide, and that aniline is carried into the finished molecules of two second-generation androgen receptor inhibitors, enzalutamide and apalutamide, where the fluorinated N-methylbenzamide ring is joined through a thiohydantoin to the second aromatic half of the drug. In enzalutamide routes the amine is built into a gem-dimethyl amino acid or nitrile before cyclisation; in apalutamide routes the equivalent step uses cyclobutanone to form the spiro ring. Because the benzamide fragment passes unchanged into the API, positional isomers of the fluorine or nitro group and residual starting acid are the impurities to control, and they are agreed against the buyer's route and API specification. It is used as a starting material and intermediate in enzalutamide and apalutamide manufacture, and in medicinal chemistry programmes built on the 2-fluoro-N-methylbenzamide scaffold. Bio Green Chem supplies 2-fluoro-N-methyl-4-nitrobenzamide with the assay, related substances, water and residue specification agreed with the quotation. Regulatory documentation for pharmaceutical use is confirmed at enquiry.